Is is dyhydrocourisin tuxic

ʻO Diyddrocouriarin, hopuʻia, i hoʻohanaʻia i ka meaʻai, ua hoʻohanaʻia e like me ka comvoric, e hoʻohana pono ai ka comvoric Kāleʻa CLADC Cream, niu, cinnanon flackner; Hoʻohanaʻia ia e like me ka flavor tavor.

Is is dyhydrocourisin tuxic

ʻAʻole ponoʻo Diyddrocourisin. ʻO Diyddrocouriarin kahi huahana kūlohelohe i loaʻa ma nā kala kala kala kala. Mākaukau ia e ka hydrogenzation o ka coumarin ma ke alo o ka nickel catalyst ma 160-200 ℃ a ma lalo o ke kaomi. Hiki iā ia ke hoʻohanaʻia e like me keʻano o nā meaʻala, hydrolyzed ma Alkalinezed sult e hana ai i ka hua-hydroxyphionic o-hydroxyphionic

Kūlana paʻa

Pani a me kaʻeleʻele, mālamaʻia i kahi wahi maloʻo a maloʻo, ka wahi i loko o ka pā o ka palekana, a piha i ka pale o ka palekana. E kūʻai i loko o kahi hale kūʻai maikaʻiʻole. E haʻalele i ke ahi, ka wai. Pono e mālama i kahi kūʻokoʻa mai Mxidizer, mai hoʻohui i ka mālama mālama. Lako me nāʻano kūpono a me ka nui o nā lako ahi.

I ka noiʻi Vitro

Ma Vitro enzymatic assymatic assy, ​​doraydrocourisin indication i hoʻohālikelikeʻia-hilinaʻi o ka sirt1 (Ic50 o 208μm). Ho'ēmiʻia i nā hana sirt1 deactylase i nānāʻia ma micromolar doces (85 ± 53 a me 73m Ua hoʻopaʻaʻiaʻo Microtubule Sirrt2ʻo Dailetylase i hoʻopaʻaʻia i kahiʻano like me keʻano like me keʻano o 2956.

Ma hope o 24 mau hola o ka hōʻikeʻana, dishdrocourisin (1-5mm) i hoʻonui i ke cytototicity ma TK6 Dodydrocourisin (1-5mm) i hoʻonuiʻia i ka apoptossis ma TK6 mau laina ma TK6 i kahiʻano he nui i kahi manawa he 6-hola. A 5mm dos o diydrocourisnun i hoʻonuiʻia i ka apoptosis i hoʻonuiʻia ma kahi manawa 6-hola i ka manawa o ka papa o ka lua o TK6. Ma hope o kahi manawa hōʻike 24-hola no ka foyddrocourisin (1-5mm) i hoʻonuiʻia i ka p53 lysine 373 a me 382 a me 382 a me 382.