Ua kapa ʻia ʻo ia he "gula keʻokeʻo", a ʻo kona kaulana ma kona hopena keʻokeʻo hoʻohālikelike ʻole ma kekahi ʻaoʻao, a me ka paʻakikī a me ka nele o kona unuhi ʻana ma kekahi ʻaoʻao. ʻO ka mea kanu ʻo Glycyrrhiza glabra ke kumu o Glabridin, akā ʻo Glabridin wale nō ka helu no 0.1%-0.3% o kona ʻike holoʻokoʻa, ʻo ia hoʻi, hiki i 1000kg o Glycyrrhiza glabra ke loaʻa i 100g oʻO Glabridin, ua like ka 1g o Glabridin me ka 1g o ke gula kino.
He ʻano maʻamau ʻo Hikarigandine o nā mea kanu lāʻau, a ua ʻike ʻia kona hopena keʻokeʻo e Iapana
He mea kanu ʻo Glycyrrhiza glabra o ka genus Glycyrrhiza. ʻO Kina ka ʻāina me nā kumuwaiwai lāʻau momona loa ma ka honua, a aia ma mua o 500 mau ʻano lāʻau i hoʻohana ʻia i ka hana lapaʻau, ʻo ia ka licorice ka mea i hoʻohana nui ʻia. Wahi a nā helu helu, ʻoi aku ka nui o ka hoʻohana ʻana i ka licorice ma mua o 79%.
Ma muli o ka mōʻaukala lōʻihi o ka hoʻohana ʻana, me ka hele pū ʻana me kahi kūlana kiʻekiʻe, ʻaʻole i uhaʻi wale ka laulā o ka noiʻi ʻana i ka waiwai o ka licorice ma waena o nā palena ʻāina, akā ua hoʻonui ʻia hoʻi ka noi. Wahi a ka noiʻi, mahalo nui nā mea kūʻai aku ma Asia, ʻoi aku hoʻi ma Iapana, i nā mea hoʻonani e loaʻa ana nā mea hana lāʻau. Ua hoʻopaʻa ʻia he 114 mau mea hoʻonani lāʻau ma "Japan's General Cosmetics Raw Materials", a aia he 200 mau ʻano mea hoʻonani e loaʻa ana nā mea kanu ma Iapana.
Ua ʻike ʻia he hopena keʻokeʻo loa ia, akā he aha nā pilikia i ka hoʻohana pono ʻana?
Aia ka ʻāpana hydrophobic o ka licorice extract i nā ʻano flavonoids like ʻole. Ma ke ʻano he ʻāpana nui o kona ʻāpana hydrophobic, loaʻa i ka halo-glycyrrhizidine kahi hopena inhibitory i ka hana melanin a he hopena anti-inflammatory a me anti-oxidant hoʻi.
Ua hōʻike kekahi mau ʻikepili hoʻokolohua he 232 mau manawa ke kiʻekiʻe o ka hopena keʻokeʻo o ka Glabridin māmā ma mua o ka huaora C maʻamau, 16 mau manawa ke kiʻekiʻe ma mua o ka hydroquinone, a he 1,164 mau manawa ke kiʻekiʻe ma mua o ka arbutin. No ke ʻano e hoʻokō ai i ka hana keʻokeʻo ikaika, hāʻawi ka Glabridin māmā i ʻekolu mau ala like ʻole.
1. Ka pale ʻana i ka hana tyrosinase
ʻO ke ʻano hana keʻokeʻo nui oʻO GlabridinʻO ke ʻano o ka hana, ʻo ia ke kāohi ʻana i ka synthesis o ka melanin ma o ka hoʻokūkū hoʻopaʻa ʻana i ka hana tyrosinase, e lawe ana i kahi ʻāpana o ka tyrosinase mai ke apo catalytic o ka synthesis melanin a me ka pale ʻana i ka hoʻopaʻa ʻana o ka substrate i ka tyrosinase.
2. Ka hopena antioxidant
Hiki iā ia ke kāohi i ka hana o ka tyrosinase a me ka dopa pigment interchange a me ka hana o ka dihydroxyindole carboxylic acid oxidase.
Ua hōʻike ʻia ma kahi nui o 0.1mg/ml, hiki i ka photoglycyrrhizidine ke hana ma ka ʻōnaehana hoʻomake cytochrome P450/NADOH a scavenge 67% o nā radical manuahi, nona ka hana antioxidant ikaika.
3.Inhibit i nā mea hoʻonāukiuki a kaua aku i ka UV
I kēia manawa, ua emi iho ka noiʻi i hōʻike ʻia e pili ana i ka hoʻohana ʻana o ka photoglycyrrhizidine i ke aʻo ʻana i ka photoaging ʻili i hoʻoulu ʻia e ka UV. I ka makahiki 2021, ma kahi ʻatikala ma ka puke pai koʻikoʻi ʻo Journal of Microbiology and Biotechnology, ua aʻo ʻia nā liposomes photoglycyrrhizidine no ko lākou hiki ke hoʻomaikaʻi i ka erythema i hoʻoulu ʻia e ka mālamalama UV a me nā maʻi ʻili ma ke kāohi ʻana i nā mea mumū. Hiki ke hoʻohana ʻia nā liposomes Photoglycyrrhizidine e hoʻomaikaʻi i ka bioavailability me ka liʻiliʻi o ka cytotoxicity me ka pale ʻana o ka melanin maikaʻi, e hōʻemi pono ana i ka hōʻike ʻana o nā cytokines mumū, interleukin 6 a me interleukin 10. No laila, hiki ke hoʻohana ʻia ma ke ʻano he mea lapaʻau topical e pale aku i ka hōʻino ʻili i hoʻoulu ʻia e ka radiation UV ma ke kāohi ʻana i ka mumū, kahi e hāʻawi ai i kekahi mau manaʻo no ka noiʻi ʻana i nā huahana pale keʻokeʻo o ka lā.
I ka hōʻuluʻulu manaʻo, ua ʻike ʻia ka hopena keʻokeʻo o ka photoglycyrrhizidine, akā ʻaneʻane hiki ʻole ke hoʻoheheʻe ʻia kona ʻano ponoʻī i ka wai, no laila he mea koi nui ia no ke kaʻina hana a me ka hana ʻana i ka hoʻopili ʻana o ka hoʻohui huahana mālama ʻili, a he hopena maikaʻi ia i kēia manawa ma o ka ʻenehana encapsulation liposome. Eia kekahi, kiʻiʻO GlabridinHiki i nā liposomes ke pale i ka photoaging i hoʻokomo ʻia e UV, akā pono kēia hana i nā hoʻokolohua lapaʻau hou aʻe e hōʻoia ʻia a hoʻokō ʻia nā noi noiʻi.
Nā huahana mālama ʻili e loaʻa ana ka photoGlabridin ma ke ʻano o ka hui pū ʻana o nā mea hoʻohui.
ʻOiai ʻaʻohe kānalua he hopena keʻokeʻo maikaʻi loa ka photoGlabridine, ʻoi aku ka paʻakikī o ke kumukūʻai o nā mea maka ma muli o nā pilikia i ka unuhi ʻana a me ka ʻike. I ka R&D hoʻonaninani, pili pono ka hana o ka kaohi ʻana i nā kumukūʻai i ka ʻike ʻenehana a me ke kaʻina hana ʻepekema. No laila, he ala maikaʻi ia e kaohi ai i ke kumukūʻai o nā ʻano hana a e hoʻokō i ka maikaʻi palekana a me ka maikaʻi ma ke koho ʻana i nā mea hana a me ka hoʻohui ʻana iā lākou i ka hui ʻana me ka photoglycyrrhizidine. Eia kekahi ma ka pae R&D, pono ka ʻimi hou ʻana e pili ana i ka noiʻi ʻana i nā liposomes photoglycyrrhizidine a me nā ʻano hana unuhi hou loa.
Ka manawa hoʻouna: ʻAukake-30-2022